JWH-250

JWH-250, also known as (1-pentyl-3-(1-naphthoyl)indole), is a synthetic cannabinoid research chemical, and EZRC is the first to stockpile it.

It’s a carbazole-based cannabinoid that’s the carbazole analog of JWH-018, making it ideal for researchers in countries where other cannabinoids are controlled. Like chemicals like THJ-018 and AB-PINACA, it has relatively low CB1/CB2 activity in vitro, but it’s still interesting for researchers interested in studying this type of synthetic cannabinoid.

JWH-250 , also known as  AM-250 , is a  synthetic cannabinoid  belonging to the  phenylacetylindole family . It acts as  an agonist at both CB1 and CB2 receptors , with a binding affinity (Ki) of 11 nM at CB1 and 33 nM at CB2. Unlike many older JWH series compounds, JWH-250 does not have a naphthalene ring; instead, it features a 2′-methoxy-phenylacetyl group, making it a representative of a new class of cannabinoid ligands ¹ .

History :

• JWH-250 was discovered by researcher  John W. Huffman , who created it and other compounds to study the mammalian endocannabinoid system. In May 2009, samples of JWH-250 were identified in new-generation “herbal” smoke blends, following the ban of the original ingredients (C8)-CP 47,497 and JWH-018 .

Legal status :

• Australia : It is considered a  Schedule 9 prohibited substance  in Australia (October 2015).
• United States : CB1 receptor agonists of the 3-phenylacetylindole class, such as JWH-250, are  Schedule I controlled substances .

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